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Article

Establishment of hepatitis C virus replicon cell lines possessing interferon-resistant phenotype.

Biochemical and biophysical research communications - 8 Oct 2004

Namba Katsuyuki, Naka Kazuhito, Dansako Hiromichi, Nozaki Akito, Ikeda Masanori, Shiratori Yasushi, Shimotohno Kunitada, Kato Nobuyuki

Abstract excerpt

To clarify the mechanism underlying resistance to interferon (IFN) by the hepatitis C virus (HCV) in patients with chronic hepatitis, we attempted to develop an IFN-resistant HCV replicon from the IFN-sensitive 50-1 replicon established previously. By treating 50-1 replicon cells with a prolonged low-dose treatment of IFN-alpha and then transfecting the total RNA derived from the IFN-alpha-treated replicon cells,...

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PMID: 15351737
DOI: 10.1016/j.bbrc.2004.08.091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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