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Article

Studies on hepatitis C virus resistance to inhibitors in replicon systems.

Current protocols in pharmacology - 1 Sept 2010

Zhao Yongsen, Huang Mingjun

Abstract excerpt

Viruses evolve under selection pressure from a particular antiviral agent, resulting in the emergence of organisms that are not susceptible to the drug. This process is referred to as "virus resistance induction." While conventional in vitro resistance studies are conducted using infectious viruses, the lack of a robust hepatitis C virus (HCV) infection system in cell culture makes such an approach impossible in...

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PMID: 22294367
DOI: 10.1002/0471141755.ph13b02s50

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