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Article

Effect of Alpha Interferon on the Hepatitis C Virus Replicon

15 Sept 2001

Abstract excerpt

Chronic hepatitis C virus (HCV) infections can be cured only in a fraction of patients treated with alpha interferon (IFN-alpha) and ribavirin combination therapy. The mechanism of the IFN-alpha response against HCV is not understood, but evidence for a role for viral nonstructural protein 5A (NS5A) in IFN resistance has been provided. To elucidate the mechanism by which NS5A and possibly other viral proteins...

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PMID: 11507197
DOI: 10.1128/jvi.75.18.8516-8523.2001

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