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Article

Preexisting drug-resistance mutations reveal unique barriers to resistance for distinct antivirals.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jun 2011

Robinson Margaret, Tian Yang, Delaney William E, Greenstein Andrew E

Abstract excerpt

Clinical trials of direct-acting antiviral agents in patients chronically infected with hepatitis C virus (HCV) have demonstrated that viral resistance is detected rapidly during monotherapy. In patients, HCV does not exist as a single, genetically homogenous virus but rather as a population of variants termed "quasispecies." Preexisting variants resistant to specific antiviral drugs, overlooked in traditional...

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Identifiers

PMID: 21646519
DOI: 10.1073/pnas.1101515108
PMCID: PMC3121856

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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