Article
HCV antiviral resistance: the impact of in vitro studies on the development of antiviral agents targeting the viral NS5B polymerase.
Antiviral chemistry & chemotherapy - 1 Jan 2005
Tomei Licia, Altamura Sergio, Paonessa Giacomo, De Francesco Raffaele, Migliaccio Giovanni
Abstract excerpt
The high prevalence of the disease caused by hepatitis C virus (HCV) and the limited efficacy of interferon-based therapies have stimulated the search for safer and more effective drugs. The development of inhibitors of the HCV NS5B RNA polymerase represents a promising strategy for identifying novel anti-HCV therapeutics. However, the high genetic diversity, mutation rate and turnover of HCV are expected to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.