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Article

Hydrophobic sequences target and anchor perilipin A to lipid droplets.

Journal of lipid research - 1 Nov 2004

Subramanian Vidya, Garcia Anne, Sekowski Anna, Brasaemle Dawn L

Abstract excerpt

Perilipins regulate triacylglycerol storage and hydrolysis in adipocytes. The central 25% of the perilipin A sequence, including three hydrophobic sequences (H1, H2, and H3) and an acidic region, targets and anchors perilipins to lipid droplets. Thus, we hypothesized that H1, H2, and H3 are targeting and anchoring motifs. We now show that deletion of any single hydrophobic sequence or combinations of H1 and H3 or...

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Source

Identifiers

PMID: 15342676
DOI: 10.1194/jlr.M400291-JLR200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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