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Article

A novel conserved targeting motif found in ABCA transporters mediates trafficking to early post-Golgi compartments.

Journal of lipid research - 1 Aug 2011

Beers Michael F, Hawkins Arie, Shuman Henry, Zhao Ming, Newitt Jennifer L, Maguire Jean Ann, Ding Wenge, Mulugeta Surafel

Abstract excerpt

The ATP binding cassette, class A (ABCA) proteins are homologous polytopic transmembrane transporters that function as lipid pumps at distinct subcellular sites in a variety of cells. Located within the N terminus of these transporters, there exists a highly conserved xLxxKN motif of unknown function. To define its role, human ABCA3 was employed as a primary model representing ABCA transporters, while mouse ABCA1...

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Source

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Identifiers

PMID: 21586796
DOI: 10.1194/jlr.M013284
PMCID: PMC3139239

Genes

ABCA1
ABCA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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