Article
Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1-3.
The Journal of biological chemistry - 25 Mar 2016
Rowe Emily R, Mimmack Michael L, Barbosa Antonio D, Haider Afreen, Isaac Iona, Ouberai Myriam M, Thiam Abdou Rachid, Patel Satish, Saudek Vladimir, Siniossoglou Symeon, Savage David B
Abstract excerpt
Perilipins (PLINs) play a key role in energy storage by orchestrating the activity of lipases on the surface of lipid droplets. Failure of this activity results in severe metabolic disease in humans. Unlike all other lipid droplet-associated proteins, PLINs localize almost exclusively to the phospholipid monolayer surrounding the droplet. To understand how they sense and associate with the unique topology of the...
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