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Article

Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease.

The Journal of comparative neurology - 1 Mar 2006

Donovan Michael H, Yazdani Umar, Norris Rebekah D, Games Dora, German Dwight C, Eisch Amelia J

Abstract excerpt

Abnormal subgranular zone (SGZ) neurogenesis is proposed to contribute to Alzheimer's disease (AD)-related decreases in hippocampal function. Our goal was to examine hippocampal neurogenesis in the PDAPP mouse, a model of AD with age-dependent accumulation of amyloid-beta(42) (Abeta(42))-containing plaques that is well studied with regard to AD therapies. A secondary goal was to determine whether altered...

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PMID: 16432899
DOI: 10.1002/cne.20840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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