Article
Role for Nhp6, Gcn5, and the Swi/Snf complex in stimulating formation of the TATA-binding protein-TFIIA-DNA complex.
Molecular and cellular biology - 1 Sept 2004
Biswas Debabrata, Imbalzano Anthony N, Eriksson Peter, Yu Yaxin, Stillman David J
Abstract excerpt
The TATA-binding protein (TBP), TFIIA, and TFIIB interact with promoter DNA to form a complex required for transcriptional initiation, and many transcriptional regulators function by either stimulating or inhibiting formation of this complex. We have recently identified TBP mutants that are viable in wild-type cells but lethal in the absence of the Nhp6 architectural transcription factor. Here we show that many...
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