Article
Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex.
The EMBO journal - 3 Jun 2011
Helmlinger Dominique, Marguerat Samuel, Villén Judit, Swaney Danielle L, Gygi Steven P, Bähler Jürg, Winston Fred
Abstract excerpt
The SAGA complex is a conserved, multifunctional co-activator that has broad roles in eukaryotic transcription. Previous studies suggested that Tra1, the largest SAGA component, is required either for SAGA assembly or for SAGA recruitment by DNA-bound transcriptional activators. In contrast to Saccharomyces cerevisiae and mouse, a tra1Δ mutant is viable in Schizosaccharomyces pombe, allowing us to test these...
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