Article
A new class of histone H2A mutations in Saccharomyces cerevisiae causes specific transcriptional defects in vivo.
Molecular and cellular biology - 1 Apr 1995
Hirschhorn J N, Bortvin A L, Ricupero-Hovasse S L, Winston F
Abstract excerpt
Nucleosomes have been shown to repress transcription both in vitro and in vivo. However, the mechanisms by which this repression is overcome are only beginning to be understood. Recent evidence suggests that in the yeast Saccharomyces cerevisiae, many transcriptional activators require the SNF/SWI complex to overcome chromatin-mediated repression. We have identified a new class of mutations in the histone...
Topics
- Base Sequence
- Carrier Proteins
- Chromatin
- Gene Expression Regulation, Fungal
- Histones
- Membrane Transport Proteins
- Models, Genetic
- Molecular Sequence Data
- Mutation
- Plant Proteins
- Promoter Regions, Genetic