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Article

An array of coactivators is required for optimal recruitment of TATA binding protein and RNA polymerase II by promoter-bound Gcn4p.

Molecular and cellular biology - 1 May 2004

Qiu Hongfang, Hu Cuihua, Yoon Sungpil, Natarajan Krishnamurthy, Swanson Mark J, Hinnebusch Alan G

Abstract excerpt

Wild-type transcriptional activation by Gcn4p is dependent on multiple coactivators, including SAGA, SWI/SNF, Srb mediator, CCR4-NOT, and RSC, which are all recruited by Gcn4p to its target promoters in vivo. It was not known whether these coactivators are required for assembly of the preinitiation complex (PIC) or for subsequent steps in the initiation or elongation phase of transcription. We find that mutations...

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Source

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Identifiers

PMID: 15121833
DOI: 10.1128/MCB.24.10.4104-4117.2004
PMCID: PMC400468

Genes

TBP
ARG1
CCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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An array of coactivators is required for optimal recruitment of TATA binding protein and RNA polymerase II by promoter-bound Gcn4p.PMID 15121833Read ↗

Simultaneous recruitment of coactivators by Gcn4p stimulates multiple steps of transcription in vivo.Semantic proximity Read ↗

A multiplicity of coactivators is required by Gcn4p at individual promoters in vivo.Semantic proximity Read ↗

Recruitment of SWI/SNF by Gcn4p does not require Snf2p or Gcn5p but depends strongly on SWI/SNF integrity, SRB mediator, and SAGA.Semantic proximity Read ↗

Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex.Semantic proximity Read ↗

A triad of subunits from the Gal11/tail domain of Srb mediator is an in vivo target of transcriptional activator Gcn4p.Semantic proximity Read ↗

SWI/SNF-dependent chromatin remodeling of RNR3 requires TAF(II)s and the general transcription machinery.Semantic proximity Read ↗

yTAFII61 has a general role in RNA polymerase II transcription and is required by Gcn4p to recruit the SAGA coactivator complex.Semantic proximity Read ↗

Role for Nhp6, Gcn5, and the Swi/Snf complex in stimulating formation of the TATA-binding protein-TFIIA-DNA complex.Semantic proximity Read ↗

The TAF9 C-terminal conserved region domain is required for SAGA and TFIID promoter occupancy to promote transcriptional activation.Semantic proximity Read ↗

Transcriptional activation by Gcn4p involves independent interactions with the SWI/SNF complex and the SRB/mediator.Semantic proximity Read ↗

The Saccharomyces cerevisiae Srb8-Srb11 complex functions with the SAGA complex during Gal4-activated transcription.Semantic proximity Read ↗

Structure of the human SAGA coactivator complex: The divergent architecture of human SAGA allows modular coordination of transcription activation and co-transcriptional splicingSemantic proximity Read ↗

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