Article

Suppressor mutations that make the essential transcription factor Spn1/Iws1 dispensable in <i>Saccharomyces cerevisiae</i>

2022-06-30

Abstract excerpt

Spn1/Iws1 is an essential eukaryotic transcription elongation factor that is conserved from yeast to humans as an integral member of the RNA polymerase II elongation complex. Several studies have shown that Spn1 functions as a histone chaperone to control transcription, RNA splicing, genome stability, and histone modifications. However, the precise role of Spn1 is not understood, and there is little understanding...

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Literature Corpus work: a3286337-c1e9-5b4b-b621-55615b6c97b0
DOI: 10.1101/2022.06.28.498004

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