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Article

Architectural transcription factors and the SAGA complex function in parallel pathways to activate transcription.

Molecular and cellular biology - 1 Apr 2000

Yu Y, Eriksson P, Stillman D J

Abstract excerpt

Recent work has shown that transcription of the yeast HO gene involves the sequential recruitment of a series of transcription factors. We have performed a functional analysis of HO regulation by determining the ability of mutations in SIN1, SIN3, RPD3, and SIN4 negative regulators to permit HO expression in the absence of certain activators. Mutations in the SIN1 (=SPT2) gene do not affect HO regulation, in...

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Identifiers

PMID: 10713159
DOI: 10.1128/MCB.20.7.2350-2357.2000
PMCID: PMC85404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Architectural transcription factors and the SAGA complex function in parallel pathways to activate transcription.PMID 10713159Read ↗

SWI/SNF binding to the HO promoter requires histone acetylation and stimulates TATA-binding protein recruitment.Semantic proximity Read ↗

Amino acid substitutions in the structured domains of histones H3 and H4 partially relieve the requirement of the yeast SWI/SNF complex for transcription.Semantic proximity Read ↗

Essential functional interactions of SAGA, a Saccharomyces cerevisiae complex of Spt, Ada, and Gcn5 proteins, with the Snf/Swi and Srb/mediator complexes.Semantic proximity Read ↗

A negative regulator of HO transcription, SIN1 (SPT2), is a nonspecific DNA-binding protein related to HMG1.Semantic proximity Read ↗

The Saccharomyces cerevisiae SIN3 gene, a negative regulator of HO, contains four paired amphipathic helix motifs.Semantic proximity Read ↗

Epistasis analysis of suppressor mutations that allow HO expression in the absence of the yeast SW15 transcriptional activator.Semantic proximity Read ↗

Role for Nhp6, Gcn5, and the Swi/Snf complex in stimulating formation of the TATA-binding protein-TFIIA-DNA complex.Semantic proximity Read ↗

Gal11 is a general activator of basal transcription, whose activity is regulated by the general repressor Sin4 in yeast.Semantic proximity Read ↗

SIN1 interacts with a protein that binds the URS1 region of the yeast HO gene.Semantic proximity Read ↗

Activation of basal transcription by a mutation in SIN4, a yeast global repressor, occurs through a mechanism different from activator-mediated transcriptional enhancement.Semantic proximity Read ↗

Repressive chromatin affects factor binding at yeast HO (homothallic switching) promoter.Semantic proximity Read ↗

The Saccharomyces cerevisiae Srb8-Srb11 complex functions with the SAGA complex during Gal4-activated transcription.Semantic proximity Read ↗

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