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Article

Topoisomerase III acts upstream of Rad53p in the S-phase DNA damage checkpoint.

Molecular and cellular biology - 1 Nov 2001

Chakraverty R K, Kearsey J M, Oakley T J, Grenon M, de La Torre Ruiz M A, Lowndes N F, Hickson I D

Abstract excerpt

Deletion of the Saccharomyces cerevisiae TOP3 gene, encoding Top3p, leads to a slow-growth phenotype characterized by an accumulation of cells with a late S/G2 content of DNA (S. Gangloff, J. P. McDonald, C. Bendixen, L. Arthur, and R. Rothstein, Mol. Cell. Biol. 14:8391-8398, 1994). We have investigated the function of TOP3 during cell cycle progression and the molecular basis for the cell cycle delay seen in...

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Identifiers

PMID: 11585898
DOI: 10.1128/MCB.21.21.7150-7162.2001
PMCID: PMC99890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Topoisomerase III acts upstream of Rad53p in the S-phase DNA damage checkpoint.PMID 11585898Read ↗

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Human TopBP1 Ensures Genome Integrity during Normal S PhaseSemantic proximity Read ↗

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The top3(+) gene is essential in Schizosaccharomyces pombe and the lethality associated with its loss is caused by Rad12 helicase activity.Semantic proximity Read ↗

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