Article
Mutations in homologous recombination genes rescue top3 slow growth in Saccharomyces cerevisiae.
Genetics - 1 Oct 2002
Shor Erika, Gangloff Serge, Wagner Marisa, Weinstein Justin, Price Gavrielle, Rothstein Rodney
Abstract excerpt
In budding yeast, loss of topoisomerase III, encoded by the TOP3 gene, leads to a genomic instability phenotype that includes slow growth, hyper-sensitivity to genotoxic agents, mitotic hyper-recombination, increased chromosome missegregation, and meiotic failure. Slow growth and other defects of top3 mutants are suppressed by mutation of SGS1, which encodes the only RecQ helicase in S. cerevisiae. sgs1 is...
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