Article
The essential role of yeast topoisomerase III in meiosis depends on recombination.
The EMBO journal - 15 Mar 1999
Gangloff S, de Massy B, Arthur L, Rothstein R, Fabre F
Abstract excerpt
Yeast cells mutant for TOP3, the gene encoding the evolutionary conserved type I-5' topoisomerase, display a wide range of phenotypes including altered cell cycle, hyper-recombination, abnormal gene expression, poor mating, chromosome instability and absence of sporulation. In this report, an analysis of the role of TOP3 in the meiotic process indicates that top3Delta mutants enter meiosis and complete the...
Topics
- Amino Acid Sequence
- Cell Cycle
- Cell Nucleus
- Conserved Sequence
- DNA Damage
- DNA Topoisomerases, Type I
- DNA, Fungal
- Evolution, Molecular
- Gene Deletion
- Genotype
- Meiosis
- Mutagenesis