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Article

Inactivation of homologous recombination suppresses defects in topoisomerase III-deficient mutants.

DNA repair - 21 Jun 2002

Oakley Thomas J, Goodwin Adele, Chakraverty Ronjon K, Hickson Ian D

Abstract excerpt

The Saccharomyces cerevisiae TOP3 gene encodes the type IA topoisomerase (Top3p) that is highly conserved in evolution. Deletion of TOP3 leads to a reduction in cell viability, hyper-recombination between repetitive DNA sequences, and abnormalities in both cell cycle progression and responses to DNA damaging agents. Deletion of SGS1, encoding the sole RecQ family helicase in S. cerevisiae, strongly suppresses the...

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Identifiers

PMID: 12509234
DOI: 10.1016/s1568-7864(02)00032-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inactivation of homologous recombination suppresses defects in topoisomerase III-deficient mutants.PMID 12509234Read ↗

Mutations in homologous recombination genes rescue top3 slow growth in Saccharomyces cerevisiae.Semantic proximity Read ↗

A genetic screen for top3 suppressors in Saccharomyces cerevisiae identifies SHU1, SHU2, PSY3 and CSM2: four genes involved in error-free DNA repair.Semantic proximity Read ↗

The essential role of yeast topoisomerase III in meiosis depends on recombination.Semantic proximity Read ↗

Requirement for Schizosaccharomyces pombe Top3 in the maintenance of chromosome integrity.Semantic proximity Read ↗

Genetic analysis of the Saccharomyces cerevisiae Sgs1 helicase defines an essential function for the Sgs1-Top3 complex in the absence of SRS2 or TOP1.Semantic proximity Read ↗

The genetic consequences of ablating helicase activity and the Top3 interaction domain of Sgs1.Semantic proximity Read ↗

Genome rearrangement in top3 mutants of Saccharomyces cerevisiae requires a functional RAD1 excision repair gene.Semantic proximity Read ↗

Topoisomerase III is essential for accurate nuclear division in Schizosaccharomyces pombe.Semantic proximity Read ↗

Topoisomerase III acts upstream of Rad53p in the S-phase DNA damage checkpoint.Semantic proximity Read ↗

Top3 processes recombination intermediates and modulates checkpoint activity after DNA damage.Semantic proximity Read ↗

SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination.Semantic proximity Read ↗

Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair.Semantic proximity Read ↗

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