Article
Top3 processes recombination intermediates and modulates checkpoint activity after DNA damage.
Molecular biology of the cell - 1 Oct 2006
Mankouri Hocine W, Hickson Ian D
Abstract excerpt
Mutation of TOP3 in Saccharomyces cerevisiae causes poor growth, hyperrecombination, and a failure to fully activate DNA damage checkpoints in S phase. Here, we report that overexpression of a dominant-negative allele of TOP3, TOP3(Y356F), which lacks the catalytic (decatenation) activity of Top3, causes impaired S-phase progression and the persistence of abnormal DNA structures (X-shaped DNA molecules) after...
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