Article
Frequency of the G/G genotype of resistin single nucleotide polymorphism at -420 appears to be increased in younger-onset type 2 diabetes.
Diabetes - 1 Nov 2007
Ochi Masaaki, Osawa Haruhiko, Hirota Yushi, Hara Kazuo, Tabara Yasuharu, Tokuyama Yoshiharu, Shimizu Ikki, Kanatsuka Azuma, Fujii Yasuhisa, Ohashi Jun, Miki Tetsuro, Nakamura Naoto, Kadowaki Takashi, Itakura Mitsuo, Kasuga Masato, Makino Hideichi
Abstract excerpt
OBJECTIVE: Resistin is an adipocyte-secreted cytokine associated with insulin resistance in mice. We previously reported that the G/G genotype of a resistin single nucleotide polymorphism (SNP) at -420 increases type 2 diabetes susceptibility by enhancing its promoter activity. The aim of the present study was to determine the relevance of SNP -120 in a large number of subjects. RESEARCH DESIGN AND METHODS: We...
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