Article
Interleukin-1 gene cluster polymorphisms and risk of Alzheimer's disease in Chinese Han population.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Sept 2004
Li X-Q, Zhang J-W, Zhang Z-X, Chen D, Qu Q-M
Abstract excerpt
Interleukin-1 (IL-1) has been implicated as a key cytokine in Alzheimer's disease (AD) pathogenesis. IL-1 gene polymorphisms, especially IL-1A C((-)889)T polymorphism, have been suggested to be associated with AD risk and onset age. To determine if IL-1 polymorphisms are genetic risk factors for developing AD in Chinese Mainland population, we analyzed IL-1A ((-)889), IL-1B ((-)511) and IL-1RN variable number of...
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