Article
Genotypes and haplotypes in the IL-1 gene cluster: analysis of two genetically and diagnostically distinct groups of Alzheimer patients.
Neurobiology of aging - 1 Apr 2005
Seripa Davide, Matera Maria G, Dal Forno Gloria, Gravina Carolina, Masullo Carlo, Daniele Antonio, Binetti Giuliano, Bonvicini Cristian, Squitti Rosanna, Palermo Mark T, Davis Daron G, Antuono P, Wekstein David R, Dobrina Aldo, Gennarelli Massimo, Fazio Vito M
Abstract excerpt
Increased risk of Alzheimer's disease (AD) has been associated with polymorphisms in the IL-1 gene cluster, and in particular with the IL-1alpha-889 T/T genotype. However, this association is still unclear, and needs further investigation. In order to clarify the role of these polymorphisms in the complex pathogenesis of AD we examined genotype and haplotype frequencies of the two C-to-T SNPs at position -889 and...
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