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Article

Association of interleukin-1 gene polymorphisms with dementia in a community-based sample: the Honolulu-Asia Aging Study.

Neurobiology of aging - 1 Feb 2006

Yucesoy Berran, Peila Rita, White Lon R, Wu Kim Ming, Johnson Victor J, Kashon Michael L, Luster Michael I, Launer Lenore J

Abstract excerpt

The interleukin-1 (IL-1) pro-inflammatory cytokine family participates in inflammatory processes and vessel damage involved in neurodegeneration. Recent studies suggest that Alzheimer's disease (AD) and vascular dementia (VaD) may share genetic risk factors. In this study, the frequency of polymorphisms in the genes coding for interleukin (IL)-1alpha, IL-1beta and the IL-1 receptor antagonist (RN) and their...

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PMID: 16226351
DOI: 10.1016/j.neurobiolaging.2005.01.013

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