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Interleukin-1alpha and -1beta promoter polymorphisms in Taiwanese patients with dementia.

Dementia and geriatric cognitive disorders - 1 Jan 2007

Wang Hsiu-Kuan, Hsu Wen-Chuin, Fung Hon-Chung, Lin Jun-Cheng, Hsu Hai-Pei, Wu Yih-Ru, Hsu Yuying, Hu Fen-Ju, Lee-Chen Guey-Jen, Chen Chiung-Mei

Abstract excerpt

BACKGROUND: Inflammatory events may contribute to the pathogenesis of dementia and interleukin-1 (IL-1) may exert both neurotoxic and neuroprotective effects. We investigated whether IL-1alpha -889 C/T and IL-1beta -511 C/T promoter polymorphisms are associated with the risk of Alzheimer's disease (AD) and vascular dementia (VaD). METHODS: AD patients (n = 219) and VaD patients (n = 82), who fulfilled the...

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Alzheimer Disease
Dementia, Vascular
Genetic Carrier Screening
Interleukin-1alpha
Interleukin-1beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multivariate Analysis

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PMID: 17622713
DOI: 10.1159/000104829

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