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Article

Association of interleukin 1β polymorphisms and haplotypes with Alzheimer's disease.

Journal of neuroimmunology - 15 Jun 2012

Payão Spencer Luiz Marques, Gonçalves Gisela Moraes, de Labio Roger William, Horiguchi Lie, Mizumoto Igor, Rasmussen Lucas Trevizani, de Souza Pinhel Marcela Augusta, Silva Souza Dorotéia Rossi, Bechara Marcelo Dib, Chen Elizabeth, Mazzotti Diego Robles, Ferreira Bertolucci Paulo Henrique, Cardoso Smith Marília de Arruda

Abstract excerpt

Our study aimed to associate IL-1β and IL-1RN polymorphisms with AD disease in comparison with elderly control group from São Paulo - Brazil. We genotyped 199 Alzheimer's disease (AD) patients, 165 elderly control and 122 young control samples, concerning VNTR (IL-1RN) and -511C>T and -31T>C (IL-1β) polymorphisms. Our findings revealed that -511C/-31T/2-repetitions VNTR haplotype had a protective effect for AD...

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Haplotypes
Aged, 80 and over
Alzheimer Disease
Brazil

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin 1 Receptor Antagonist Protein

Interleukin-1beta

Minisatellite Repeats

Polymorphism, Genetic

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Identifiers

PMID: 22498095
DOI: 10.1016/j.jneuroim.2012.03.012

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