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Article

Interaction between matrix metalloproteinase 3 and the epsilon4 allele of apolipoprotein E increases the risk of Alzheimer's disease in Finns.

Neuroscience letters - 9 Sept 2004

Saarela Marika S, Lehtimäki Terho, Rinne Juha O, Hervonen Antti, Jylhä Marja, Röyttä Matias, Ahonen Jukka-Pekka, Mattila Kari M

Abstract excerpt

Polymorphisms affecting the expression of matrix metalloproteinases (MMPs), i.e. proteolytic enzymes that degrade intercellular material, have been found at position -1607 (1G/2G) in MMP1 and at -1171 (5A/6A) in MMP3. Interestingly, elevated levels of MMP1 and MMP3 have been observed in the brain...

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Source

Identifiers

PMID: 15337261
DOI: 10.1016/j.neulet.2004.06.027

Genes

MMP3
APOE
MMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15337261-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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