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Article

Interaction between matrix metalloproteinase 3 and the epsilon4 allele of apolipoprotein E increases the risk of Alzheimer's disease in Finns.

Neuroscience letters - 9 Sept 2004

Saarela Marika S, Lehtimäki Terho, Rinne Juha O, Hervonen Antti, Jylhä Marja, Röyttä Matias, Ahonen Jukka-Pekka, Mattila Kari M

Abstract excerpt

Polymorphisms affecting the expression of matrix metalloproteinases (MMPs), i.e. proteolytic enzymes that degrade intercellular material, have been found at position -1607 (1G/2G) in MMP1 and at -1171 (5A/6A) in MMP3. Interestingly, elevated levels of MMP1 and MMP3 have been observed in the brains of Alzheimer's disease (AD) patients and those of tissue inhibitors of MMPs in the cerebrospinal fluid of AD and...

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Source

Identifiers

PMID: 15337261
DOI: 10.1016/j.neulet.2004.06.027

Genes

MMP3
APOE
MMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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