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Article

The role of matrix metalloproteinase-9 in dementia.

Neuroscience letters - 30 Oct 2003

Helbecque Nicole, Hermant Xavier, Cottel Dominique, Amouyel Philippe

Abstract excerpt

Neurofibrillary tangles and senile plaques, constituted of extracellular amyloid deposits (Abeta), are the two defining pathological hallmarks of Alzheimer's disease (AD). Inhibiting the synthesis or aggregation of Abeta or increasing its clearance may reduce the detrimental effects of this peptide and consequently improve cognitive functions in patients. Previous studies indicated that metalloproteinases are...

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Identifiers

PMID: 14550924
DOI: 10.1016/s0304-3940(03)00905-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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