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Article

A single nucleotide polymorphism in the matrix metalloproteinase-3 promoter enhances breast cancer susceptibility.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2002

Ghilardi Giorgio, Biondi Maria Luisa, Caputo Maria, Leviti Simona, DeMonti Marco, Guagnellini Emma, Scorza Roberto

Abstract excerpt

PURPOSE: Matrix metalloproteinases (MMPs) are likely to be involved in invasion and metastasis of several tumors by degrading the extracellular matrix. A single adenine insertion/deletion polymorphism (5A/6A) in the MMP-3 promoter region causes the elevation of transcriptional level and local expression of MMP-3. The aim of this pilot study was to evaluate the impact of this 5A/6A polymorphism on susceptibility...

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PMID: 12473595

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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