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Article

Impact of the matrix metalloproteinase MMP-3 on dementia.

Neurobiology of aging - 1 Aug 2007

Helbecque Nicole, Cottel Dominique, Hermant Xavier, Amouyel Philippe

Abstract excerpt

Cerebral accumulation of beta-amyloid peptide (Abeta) is a central event in the pathogenesis of Alzheimer's disease (AD). Several proteases were shown to hydrolyze Abeta in vitro or in cell-based assays, and are likely candidates for a role in Abeta clearance in brain. Previous reports suggest th...

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Source

Identifiers

PMID: 16822591
DOI: 10.1016/j.neurobiolaging.2006.05.030

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16822591-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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