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Matrix metalloproteinase 3 haplotypes and plasma amyloid beta levels: the Rotterdam Study.

Neurobiology of aging - 1 Apr 2010

Reitz Christiane, van Rooij Frank J A, Soares Holly D, de Maat Moniek P M, Hofman Albert, Witteman Jacqueline C M, Breteler Monique M B

Abstract excerpt

Experimental studies suggest that matrix metalloproteinases (MMPs) are involved in the degradation of amyloid beta (Abeta) protein which plays a key role in the pathogenesis of Alzheimer's disease. Whether MMPs are associated with changes in beta amyloid levels in humans remains unclear. We related common haplotypes within the gene encoding MMP-3 with plasma levels of Abeta(1-40) and Abeta(1-42) in 1621...

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PMID: 18606478
DOI: 10.1016/j.neurobiolaging.2008.05.033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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