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Article

Matrix metalloproteinase 3 haplotypes and dementia and Alzheimer's disease. The Rotterdam Study.

Neurobiology of aging - 1 Jun 2008

Reitz Christiane, van Rooij Frank J A, de Maat Moniek P M, den Heijer Tom, Hofman Albert, Witteman Jacqueline C M, Breteler Monique M B

Abstract excerpt

Evidence by post-mortem and animal studies suggests that matrix metalloproteinases (MMPs) may play an important role in the pathophysiology of Alzheimer's disease (AD) through degradation of amyloid beta. We investigated in 5999 elderly whether MMP3-haplotypes are associated with cognitive perfor...

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Source

Identifiers

PMID: 17316907
DOI: 10.1016/j.neurobiolaging.2007.01.001

Genes

MMP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17316907-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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