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Article

Analysis of functional polymorphisms of metalloproteinase genes in persons with vascular dementia and Alzheimer's disease.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Oct 2006

Flex Andrea, Gaetani Eleonora, Proia Anna S, Pecorini Giovanni, Straface Giuseppe, Biscetti Federico, Fioroni Giuseppe, Sabusco Alexandra, Flore Roberto, Tondi Paolo, Pola Paolo, Pola Roberto

Abstract excerpt

BACKGROUND: Vascular dementia (VAD) and Alzheimer's disease (AD) may share common neuropathological mechanisms. Matrix metalloproteinases (MMPs) may induce destruction of the extracellular matrix, neuronal dysfunction, and death. Increased expression of these molecules has been found in a number of neurological diseases, including cerebral ischemia and AD. Expression and activity of MMPs may be genetically...

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Source

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PMID: 17077200
DOI: 10.1093/gerona/61.10.1065

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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