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14-3-3 zeta and tau genes interactively decrease Alzheimer's disease risk.

Dementia and geriatric cognitive disorders - 1 Jan 2008

Mateo Ignacio, Sánchez-Juan Pascual, Rodríguez-Rodríguez Eloy, Infante Jon, Fernández-Viadero Carlos, Peña Nicolás, Berciano José, Combarros Onofre

Abstract excerpt

Abnormal tau hyperphosphorylation has been suggested as being one of the central events in the development of neurofibrillary tangles, which are one of the characteristic neuropathological lesions found in Alzheimer's disease (AD) brains. 14-3-3 zeta protein is associated with tau in brain and stimulates tau phosphorylation. In a case-control study in 293 AD patients and 396 healthy controls, we examined whether...

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PMID: 18319590
DOI: 10.1159/000119123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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