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Article

Hypermutability in a Drosophila model for multiple endocrine neoplasia type 1.

Human molecular genetics - 15 Oct 2004

Busygina Valeria, Suphapeetiporn Kanya, Marek Lorri R, Stowers R Steven, Xu Tian, Bale Allen E

Abstract excerpt

Multiple endocrine neoplasia type I (MEN1) is an autosomal dominant cancer predisposition syndrome, the gene for which encodes a nuclear protein, menin. The biochemical function of this protein has not been completely elucidated, but several studies have shown a role in transcriptional modulation through recruitment of histone deacetylase. The mechanism by which MEN1 mutations cause tumorigenesis is unknown. The...

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Identifiers

PMID: 15333582
DOI: 10.1093/hmg/ddh271

Genes

MEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypermutability in a Drosophila model for multiple endocrine neoplasia type 1.PMID 15333582Read ↗

Menin links the stress response to genome stability in Drosophila melanogaster.Semantic proximity Read ↗

Multiple Endocrine Neoplasia Type 1 Interacts with Forkhead Transcription Factor CHES1 in DNA Damage ResponseSemantic proximity Read ↗

MEN1 and FANCD2 mediate distinct mechanisms of DNA crosslink repair.Semantic proximity Read ↗

Broad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1Semantic proximity Read ↗

A large-scale screen for mutagen-sensitive loci in Drosophila.Semantic proximity Read ↗

Menin: the protein behind the MEN1 syndrome.Semantic proximity Read ↗

Kmt2acooperates with menin to suppress tumorigenesis in mouse pancreatic isletsSemantic proximity Read ↗

Characterization of DNA damage-dependent cell cycle checkpoints in a menin-deficient model.Semantic proximity Read ↗

Twenty years of menin: emerging opportunities for restoration of transcriptional regulation in MEN1Semantic proximity Read ↗

Genetic interactions between Drosophila melanogaster menin and Jun/Fos.Semantic proximity Read ↗

High incidence of mammary intraepithelial neoplasia development in Men1-disrupted murine mammary glands.Semantic proximity Read ↗

MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage responseSemantic proximity Read ↗

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