Article
Genetic interactions between Drosophila melanogaster menin and Jun/Fos.
Developmental biology - 1 Oct 2006
Cerrato Aniello, Parisi Michael, Santa Anna Sonia, Missirlis Fanis, Guru Siradanahalli, Agarwal Sunita, Sturgill David, Talbot Thomas, Spiegel Allen, Collins Francis, Chandrasekharappa Settara, Marx Stephen, Oliver Brian
Abstract excerpt
Menin is a tumor suppressor required to prevent multiple endocrine neoplasia in humans. Mammalian menin protein is associated with chromatin modifying complexes and has been shown to bind a number of nuclear proteins, including the transcription factor JunD. Menin shows bidirectional effects acting positively on c-Jun and negatively on JunD. We have produced protein null alleles of Drosophila menin (mnn1) and...
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