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Article

Menin missense mutants associated with multiple endocrine neoplasia type 1 are rapidly degraded via the ubiquitin-proteasome pathway.

Molecular and cellular biology - 1 Aug 2004

Yaguchi Hiroko, Ohkura Naganari, Takahashi Maho, Nagamura Yuko, Kitabayashi Issay, Tsukada Toshihiko

Abstract excerpt

MEN1 is a tumor suppressor gene that is responsible for multiple endocrine neoplasia type 1 (MEN1) and that encodes a 610-amino-acid protein, called menin. While the majority of germ line mutations identified in MEN1 patients are frameshift and nonsense mutations resulting in truncation of the menin protein, various missense mutations have been identified whose effects on menin activity are unclear. For this...

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Identifiers

PMID: 15254225
DOI: 10.1128/MCB.24.15.6569-6580.2004
PMCID: PMC444842

Genes

MEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Menin missense mutants associated with multiple endocrine neoplasia type 1 are rapidly degraded via the ubiquitin-proteasome pathway.PMID 15254225Read ↗

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