Article
A large-scale screen for mutagen-sensitive loci in Drosophila.
Genetics - 1 May 2004
Laurencon Anne, Orme Charisse M, Peters Heather K, Boulton Christina L, Vladar Eszter K, Langley Sasha A, Bakis Emmanuel P, Harris David T, Harris Nathan J, Wayson Sarah M, Hawley R Scott, Burtis Kenneth C
Abstract excerpt
In a screen for new DNA repair mutants, we tested 6275 Drosophila strains bearing homozygous mutagenized autosomes (obtained from C. Zuker) for hypersensitivity to methyl methanesulfonate (MMS) and nitrogen mustard (HN2). Testing of 2585 second-chromosome lines resulted in the recovery of 18 mutants, 8 of which were alleles of known genes. The remaining 10 second-chromosome mutants were solely sensitive to MMS...
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