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Article

MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response

21 Feb 2020

Abstract excerpt

Abstract The MEN1 gene, a tumor suppressor gene that encodes the protein menin, is mutated at high frequencies in neuroendocrine (NE) tumors; however, the biological importance of this gene in NE-type lung cancer in vivo remains unclear. Here, we established an ATII-specific Kras G12D/+ / Men1 −/− driven genetically engineered mouse model and show that deficiency of menin results in the accumulation of DNA damage...

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PMID: 32081882
DOI: 10.1038/s41467-020-14614-4

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