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Article

A mutant of Sindbis virus which is able to replicate in cells with reduced CTP makes a replicase/transcriptase with a decreased Km for CTP.

Journal of virology - 1 Sept 2004

Li Mei-Ling, Lin Yen-Huei, Simmonds H Anne, Stollar Victor

Abstract excerpt

We reported earlier the isolation and characterization of a Sindbis virus mutant, SV(PZF), that can grow in mosquito cells treated with pyrazofurin (PZF), a compound that interferes with pyrimidine biosynthesis (Y. H. Lin, P. Yadav, R. Ravatn, and V. Stollar, Virology 272:61-71, 2000; Y. H. Lin, H. A. Simmonds, and V. Stollar, Virology 292:78-86, 2002). Three amino acid changes in nsP4, the viral RNA polymerase,...

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Identifiers

PMID: 15331697
DOI: 10.1128/JVI.78.18.9645-9651.2004
PMCID: PMC515026

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Source receipt: pubmed, retrieved 7 Sept 2026.

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