A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase.

doi:10.1128/JVI.80.1.149-160.2006

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Article

A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase.

Journal of virology - 1 Jan 2006

Paeshuyse Jan, Leyssen Pieter, Mabery Eric, Boddeker Nina, Vrancken Robert, Froeyen Matheus, Ansari Israrul H, Dutartre Hélène, Rozenski Jef, Gil Laura H V G, Letellier Carine, Lanford Robert, Canard Bruno, Koenen Frank, Kerkhofs Pierre, Donis Ruben O, Herdewijn Piet, Watson Julia, De Clercq Erik, Puerstinger Gerhard, Neyts Johan

Abstract excerpt

We report on the highly potent and selective antipestivirus activity of 5-[(4-bromophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine (BPIP). The 50% effective concentration (EC50) for inhibition of bovine viral diarrhea virus (BVDV)-induced cytopathic effect formation was 0.04 +/- 0.01 microM. Comparable reduction of viral RNA synthesis (EC50 = 0.12 +/- 0.02 microM) and production of infectious virus (EC50= 0.074...

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Identifiers

PMID: 16352539
DOI: 10.1128/JVI.80.1.149-160.2006
PMCID: PMC1317535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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