Mutations that confer resistance to mycophenolic acid and ribavirin on Sindbis virus map to the nonstructural protein nsP1.

doi:10.1016/0042-6822(91)90881-b

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Article

Mutations that confer resistance to mycophenolic acid and ribavirin on Sindbis virus map to the nonstructural protein nsP1.

Virology - 1 Apr 1991

Scheidel L M, Stollar V

Abstract excerpt

SVMPA, a mutant of Sindbis virus derived by serial passage on Aedes albopictus mosquito cells maintained after infection in the presence of mycophenolic acid (MPA), is resistant not only to MPA but also to ribavirin. Both of these compounds inhibit the synthesis of GMP and thereby reduce the leve...

Topics

Aedes
Amino Acid Sequence
Animals
Base Sequence
Capsid
Cloning, Molecular
Drug Resistance, Microbial
Genes, Viral
Molecular Sequence Data
Mutation
Mycophenolic Acid
Phenotype
RNA, Messenger
Ribavirin
Sindbis Virus
Viral Core Proteins
Viral Nonstructural Proteins
tRNA Methyltransferases

Source

Open in PubMed

Identifiers

PMID: 1826574
DOI: 10.1016/0042-6822(91)90881-b

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1826574-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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