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Article

Mutagenesis of the conserved 51-nucleotide region of Sindbis virus.

Journal of virology - 1 Apr 1990

Niesters H G, Strauss J H

Abstract excerpt

We have constructed 25 site-specific mutations in a domain of 51 nucleotides in Sindbis virus that is highly conserved among all alphaviruses sequenced to date. These 51 nucleotides are capable of forming two hairpin structures and are found from nucleotides 155 to 205 in Sindbis virus within the region encoding nsP1. Of the mutations, 21 were silent and did not lead to a change in the amino acid sequence...

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Identifiers

PMID: 2319648
DOI: 10.1128/JVI.64.4.1639-1647.1990
PMCID: PMC249300

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