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Article

Mutations which alter the level or structure of nsP4 can affect the efficiency of Sindbis virus replication in a host-dependent manner.

Journal of virology - 1 Jun 1990

Lemm J A, Durbin R K, Stollar V, Rice C M

Abstract excerpt

Two mutants of Sindbis virus have been isolated which grow inefficiently at 34.5 degrees C in mosquito cells yet replicate normally in chicken embryo fibroblast cells at the same temperature. In addition, these mutants exhibit temperature-sensitive growth in both cell types and are RNA- at the nonpermissive temperatures (K.J. Kowal and V. Stollar, Virology 114:140-148, 1981). To clarify the basis of this host...

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Identifiers

PMID: 2159558
DOI: 10.1128/JVI.64.6.3001-3011.1990
PMCID: PMC249484

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Mutations which alter the level or structure of nsP4 can affect the efficiency of Sindbis virus replication in a host-dependent manner.PMID 2159558Read ↗

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