Article
Mutations in the nsP1 coding sequence of Sindbis virus which restrict viral replication in secondary cultures of chick embryo fibroblasts prepared from aged primary cultures.
Virology - 1 Jan 1994
Rosenblum C I, Scheidel L M, Stollar V
Abstract excerpt
SVMPA, a mutant of Sindbis virus (SV), which is able to replicate in Aedes albopictus cells treated with mycophenolic acid (MPA) or ribavirin, also has a host range phenotype. This phenotype is most clearly demonstrated by means of efficiency of plaquing (EOP) assays on secondary chick embryo fib...
Topics
- Aedes
- Animals
- Cells, Cultured
- Chick Embryo
- Cricetinae
- Fibroblasts
- Mutagenesis, Site-Directed
- Mutation
- Phenotype
- RNA, Viral
- Sindbis Virus
- Species Specificity
- Viral Nonstructural Proteins
- Virus Replication