Article
Retroviral capsid determinants of Fv1 NB and NR tropism.
Journal of virology - 1 Sept 2004
Stevens Anthony, Bock Michael, Ellis Scott, LeTissier Paul, Bishop Kate N, Yap Melvyn W, Taylor Willie, Stoye Jonathan P
Abstract excerpt
The specificity determinants for susceptibility to resistance by the Fv1 n and b alleles map to amino acid 110 of the murine leukemia virus CA protein. To study the interaction between Fv1 and CA, we examined changes in CA resulting in the loss of susceptibility to Fv1 resistance in naturally occurring NB- and NR-tropic viruses. A variety of amino acid changes affecting Fv1 tropism were identified, at CA...
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