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Article

Origin, antiviral function and evidence for positive selection of the gammaretrovirus restriction gene Fv1 in the genus Mus.

Proceedings of the National Academy of Sciences of the United States of America - 3 Mar 2009

Yan Yuhe, Buckler-White Alicia, Wollenberg Kurt, Kozak Christine A

Abstract excerpt

The Fv1 virus resistance gene is a coopted endogenous retrovirus (ERV) sequence related to the gag gene of the MuERV-L ERV family. Three major Fv1 resistance alleles have been identified in laboratory mice, and they target virus capsid genes to produce characteristic patterns of resistance to mouse leukemia viruses (MLVs). We identified Fv1 in 3 of the 4 Mus subgenera; its absence from Coelomys and 1 of 3 species...

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Identifiers

PMID: 19221034
DOI: 10.1073/pnas.0900181106
PMCID: PMC2651326

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