Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Species-Specific Tropism Determinants in the Human Immunodeficiency Virus Type 1 Capsid

12 May 2004

Abstract excerpt

Retroviral tropism is determined in part by cellular restriction factors that block infection by targeting the incoming viral capsid. Indeed, human immunodeficiency virus type 1 (HIV-1) infection of many nonhuman primate cells is inhibited by one such factor, termed Lv1. In contrast, a restriction factor in humans, termed Ref1, does not inhibit HIV-1 infection unless nonnatural mutations are introduced into the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV/AIDS drug development and treatment
Share to HIV/AIDS Research and Interventions
Share to HIV Research and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15140998
DOI: 10.1128/jvi.78.11.6005-6012.2004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Species-Specific Tropism Determinants in the Human Immunodeficiency Virus Type 1 CapsidPMID 15140998Read ↗

HIV-1 capsid variability: viral exploitation and evasion of capsid-binding moleculesSemantic proximity Read ↗

RNA-Associated Early-Stage Antiviral Factor Is a Major Component of Lv2 RestrictionSemantic proximity Read ↗

Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5αSemantic proximity Read ↗

Lv2, a Novel Postentry Restriction, Is Mediated by both Capsid and EnvelopeSemantic proximity Read ↗

Virological characterization of HIV-1 CA-NTD mutants constructed in a virus-lineage reflected manner.Semantic proximity Read ↗

Capsid-binding retrovirus restriction factors: discovery, restriction specificity and implications for the development of novel therapeuticsSemantic proximity Read ↗

Impact of HIV-1 capsid polymorphisms on viral infectivity and susceptibility to lenacapavirSemantic proximity Read ↗

Naturally Occurring Mutations in HIV-1 CRF01_AE Capsid Affect Viral Sensitivity to Restriction Factors.Semantic proximity Read ↗

A Single Amino Acid of the Human Immunodeficiency Virus Type 2 Capsid Affects Its Replication in the Presence of Cynomolgus Monkey and Human TRIM5αsSemantic proximity Read ↗

HIV-1 Capsid-Targeting Domain of Cleavage and Polyadenylation Specificity Factor 6Semantic proximity Read ↗

Lv1 Inhibition of Human Immunodeficiency Virus Type 1 Is Counteracted by Factors That Stimulate Synthesis or Nuclear Translocation of Viral cDNASemantic proximity Read ↗

Preclinical virology profiles of the HIV-1 capsid inhibitors VH4004280 and VH4011499Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.