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Article

Distinct dose-dependent cortical neuronal migration and neurite extension defects in Lis1 and Ndel1 mutant mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 Dec 2009

Youn Yong Ha, Pramparo Tiziano, Hirotsune Shinji, Wynshaw-Boris Anthony

Abstract excerpt

Haploinsufficiency of LIS1 results in lissencephaly, a human neuronal migration disorder. LIS1 is a microtubule- (MT) and centrosome- [microtubule organizing center (MTOC)] associated protein that regulates nucleokinesis via the regulation of dynein motor function and localization. NDEL1 (NudE isoform, NudE like) interacts with LIS1/dynein complex, and is phosphorylated by CDK5/P35. Previous reports using...

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Identifiers

PMID: 20007476
DOI: 10.1523/JNEUROSCI.4630-09.2009
PMCID: PMC2824645

Genes

NDEL1
CDK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Distinct dose-dependent cortical neuronal migration and neurite extension defects in Lis1 and Ndel1 mutant mice.PMID 20007476Read ↗

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Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly.Semantic proximity Read ↗

Molecular mechanisms of neuronal migration disorders, quo vadis?Semantic proximity Read ↗

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