Article
Paraoxonase 1 (PON1) gene polymorphisms and Parkinson's disease in a Finnish population.
Neuroscience letters - 2 Sept 2004
Clarimon Jordi, Eerola Johanna, Hellström Olli, Tienari Pentti J, Singleton Andrew
Abstract excerpt
Paraoxonase 1 (PON1) is involved in the metabolism and detoxification of insecticides and pesticides. Two polymorphisms within the gene affect the enzyme activity. One is a methionine to leucine change at position 54 (M54L) and the other is a glutamine to arginine variant at position 192 (Q192R). There are contrasting reports assessing the role of these variants in Parkinson's disease (PD). We performed a...
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